Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation.

J Clin Med · 2015 · PMC4366058 · PMID 25798290

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highly significantno p-value reported

The tyrosyl-DNA-phosphodiesterases TDP1 and TDP2 are both highly significant effectors of HPV episome stability in an siRNA screen of the DDR pathway: TDP1 knockdown caused a large gain in episome copy number while TDP2 knockdown caused a large loss [ 6 ].

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