Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice.

PLoS One · 2015 · PMC4366384 · PMID 25790234

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did not achieve significanceno p-value reported

PF-05231023 administered at 0.03 mg/kg displayed a trend towards decreased AUC which did not achieve significance compared to vehicle.

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