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Influence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass Spectrometry.

PLoS One · 2015 · PMC4370500 · PMID 25799182

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a decreasing trendno p-value reported
[ 28 ] also observed a decreasing trend following the maximal crosslinking levels in T7 DNA treated with BCNU, CCNU and MeCCNU using a fluorescent assay.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.