In this study, overexpression of miR-517a/b and miR-517c resulted in a highly significant decrease in trophoblast invasion suggesting that the increased miR-517a/b and miR-517c seen in preeclamptic placentas may target genes known to regulate trophoblast function early in pregnancy.
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Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia.
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