Barely Significant
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Multi-generational drinking of bottled low mineral water impairs bone quality in female rats.

PLoS One · 2015 · PMC4372292 · PMID 25803851

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a decreasing trendno p-value reported
PICP in both the bNW and bPW groups were significantly lower than that in the TW group ( Fig 3A ) and ICTP also has a decreasing trend in the bPW group compared to the TW group ( Fig 3C ), while the serum BALP concentrations among the 4 groups were not significantly different ( Fig 3B ).

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