Utility of ¹⁸fluoro-deoxyglucose positron emission tomography for prognosis and response assessments in a phase 2 study of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma.

When stratifying PR/SD patients by PET status, patients who achieved PR/SD with PET-negative disease had a notable trend toward prolonged PFS versus those who remained PET-positive (median 18.2 versus 7.1 months, respectively), although the difference was not significant ( P = 0.0923). discussion In this examination of the prospective FDG-PET exploratory end point in the pivotal study of romidepsin for the treatment of relapsed/refractory PTCL, the vast majority (95%) of patients examined were FDG-PET avid at baseline, confirming previous assessments that T-cell lymphomas are almost universally PET avid [ 17 – 26 ].

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