Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.

Diabetes · 2015 · PMC4375076 · PMID 25352640

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highly significantno p-value reported

In particular, acipimox treatment resulted in a highly significant enrichment of genes involved in the tricarboxylic acid (TCA) cycle and electron transport chain (ETC), suggesting a specific effect of acipimox on mitochondrial metabolism ( Fig. 4 A ).

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