The trend estimation analysis indicated a borderline significant positive association with PCa risk per 1% increase of blood DHA concentration ( P = 0.11) but not per 0.5% increase of EPA concentration ( P = 0.32) (Figure 8 ).
Our present dose-response meta-analysis did not conservatively support a protective role of ALA, as the marginally significant negative association between PCa risk and per 0.5 g/day increment of dietary ALA was dominated by a single larger study and blood ALA concentration also showed no significant association with aggressive, non-aggressive, or total PCa risk.