Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: evidence from two independent cohorts.

(2013) who reported that at least one of these top-hits from the PGC-SZ1 study (rs17662626 near PCGEM1 ) was implicated in this prior association, and risk associated with these highly significant SNPs may produce more reliable associations with imaging phenotypes than SNPs added to a polygenic model with less stringent p thresholds and less robust ORs.

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