Although 5/10 mice harbored up to 4 adult parasites, with eggs detected in 7/10 mice at day 28, this represented a highly significant reduction compared to levels in control animals.
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Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.
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