Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring.

Importantly, when we analysed half-life across all infections (treated and untreated), there was a highly significant interaction between the effect of drug treatment and parasite genotype ( = 9.10, P < 0.0001; compare Fig. 2 B,C; Table S1.5 ), as well as significant negative correlations with pre-peak growth rate and parasite density at peak (which were independent of differences between parasite lines) (intrinsic growth rate = 4.15, P = 0.049; density at peak = 9.48, P < 0.005; Table S1.5 ).

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