Genetic factors associated with naevus count and dermoscopic patterns: preliminary results from the Study of Nevi in Children (SONIC).

Br J Dermatol · 2015 · PMC4382400 · PMID 25307738

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0600

boldest claim

The sentences

borderline significantP = 0·057so close (0.05 < p ≤ 0.1)

We found a borderline significant interaction ( anova P = 0·057).

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marginal significanceP < 0·06so close (0.05 < p ≤ 0.1)

45 , 46 We observed that another SNP ( PARP1 rs2695238) was associated with naevus count with marginal significance ( P < 0·06) and displayed an inverse association ( P = 0·05) with reticular-patterned naevi.

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borderline significanceno p-value reported

In multivariate analyses (Table 3 ), the minor alleles of IRF4 (rs12203592), PARP1 (rs3219090), CDK6 (rs2079147) and PLA2G6 (rs738322) were significantly associated with either increased (rs12203592) or decreased (rs3219090, rs2079147, rs738322) naevus count in at least one of the multivariate methods considered, and two SNPs, in PARP1 and in APEX1 , displayed borderline significance.

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