Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc.

PLoS One · 2015 · PMC4388545 · PMID 25848777

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highly significantno p-value reported

Most important was that there was a highly significant correlation between the amplitude of the sine wave, and the ovality ratio, a commonly used method to quantify the degree of the optic disc tilt.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.