Amplification of CCL2 mRNA expression induced by combined administration of IL-1 β and OSM when compared with IL-1 β stimulation alone was still highly significant in those cells in which STAT1 was silenced (Fig. 8 ).
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Synergistic induction of CCL2/MCP-1 expression driven by oncostatin M and IL-1β in human proximal tubular cells depends on STAT3 and p65 NFκB/RelA.
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