Levosimendan displays anti-inflammatory effects and decreases MPO bioavailability in patients with severe heart failure.

Mean plasma nitrite concentration as a marker of NO-production 20 was not different for the first 2 days but did show a highly significant increase after 7 days (from baseline 14.2 ± 1.1 μM to 82.3 ± 11.7 μM at 7 days, p < 0.01; figure 1 C ).

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