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Health and economic outcomes of introducing the new MenB vaccine (Bexsero) into the Italian routine infant immunisation programme.

PLoS One · 2015 · PMC4395261 · PMID 25874805

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a decreasing trendno p-value reported
Moreover, as occurred in many high-income countries in the past decade [ 8 , 27 ], also in our analysis the incidence of IMD showed a decreasing trend among all serogroups (from 0.58 to 0.28) over the last 6-year study period, even if fluctuations have been historically reported [ 10 , 66 ] suggesting that future incidence remains still uncertain.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.