Barely Significant
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Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation.

Genome Med · 2015 · PMC4395979 · PMID 25874000

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highly significantP <0.0001actually significant
Third, analysis of the tumor specific variants in BCL2 regions from FL specimens, at both high (≥15%) and low (≤1%) frequencies identified a consistent and highly significant bias towards the AID mutation patterns expected to be found in aSHM (see Additional file 4 : Figure AF1: WRCY motif P <0.0001, WA/TW motif P <0.0012 by one-tailed Fisher’s exact test [ 36 ]), strongly indicating that the identified variants at both high and low frequencies are due to a common biological process and are not a computational artifact.

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