A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease.

PLoS Genet · 2015 · PMC4398399 · PMID 25875846

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highly significantp = 3.8 x 10 -136actually significant

Genetic analyses uncovered a missense change, c.1288G>A; p.A430T, in the autophagy-related ATG4D gene on canine chromosome 20 with a highly significant disease association (p = 3.8 x 10 -136 ) in a cohort of more than 2300 Lagotto Romagnolo dogs.

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