Genomic variant representation in a Chlamydia population is dynamic and adaptive with dependence on in vitro and in vivo passage.

Over two experiments of 10 mice in each experiment (total of 20 mice and 40 oviducts assessed), we consistently observed a highly significant reduction in the rate of hydrosalpinx (Table 1 , P < 0.001, chi-square analysis with Yates correction), when compared to historical controls and a slight but statistically significant drop in the rate of hydrosalpinx in the BALB/c susceptible strain ( P < 0.04).

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