Nuclear Factor Kappa B, Matrix Metalloproteinase-1, p53, and Ki-67 Expressions in the Primary Tumors and the Lymph Node Metastases of Colorectal Cancer Cases.

Highly significant differences in the expression of MMP genes (-1, -3, -7, -9, -10, -11, -12, and -14) between primary cancers and their metastases were reported and these findings were associated with aggressive tumor behavior, though the prognostic importance of MMP expression in CRC has not been determined yet [ 16 , 33 ].

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