Although MAIT cells appear to have a lesser role against viral pathogens, the role of mucosal immunity appears to be highly significant in HIV infection [ 30 ] owing to the systemic impact mucosa derived microbe-derived components has on the infection.
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Attrition of TCR Vα7.2+ CD161++ MAIT cells in HIV-tuberculosis co-infection is associated with elevated levels of PD-1 expression.
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