Although we observed a highly significant difference in proportions of Foxp3 − and Foxp3 + T cells expressing CCR4 in spleens and lymph nodes, this difference was considerably reduced in the tumour where CCR4 was expressed on a high proportion of both Foxp3 − and Foxp3 + T cells (Fig. 3 ).
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A distinct chemokine axis does not account for enrichment of Foxp3(+) CD4(+) T cells in carcinogen-induced fibrosarcomas.
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