Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes.

The network of Figure 4 (and Additional file 3 : Figure S1) shows several interesting points: i) 5 of the deleted genes ( NVL, RTF1, TADA2A, HSPA4, FAM177A1 ) included in group 1 share a highly significant number of transcriptomic neighbors and form a dense sub-network; ii) four amplified genes, MMAB , SPRYD3 , C22orf26 and TSPAN32 are anti-correlated with a large number of positive neighbors of these 5 deleted putative drivers; iii) the amplified genes included in the expression group 2 also share transcriptomic neighbors and iv) FOXL2 is heavily connected to the deleted putative drivers, which suggests an interplay between the C134W mutation and the genomic alterations (especially the deletions) that we have detected.

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