Plasma matrix metalloproteinases, low density lipoprotein oxidisability and soluble adhesion molecules after a glucose load in Type 2 diabetes.

LDL oxidisability [Table 2 ] There was no significant difference between LDL lag times at baseline and at 90 minutes in either diabetic or controls groups, although lag times were significantly longer in the control group [p = 0.01] Discussion The prompt highly significant fall in all plasma soluble adhesion molecule concentrations following an oral glucose load in Type 2 diabetes is a surprising observation as in vitro, upregulation of membrane adhesion molecule expression and message in endothelial and other cell lines is associated with both high glucose concentrations and increased intracellular oxidative stress [ 6 - 8 ], and other smaller studies have described increased plasma concentrations of soluble adhesion molecules [particularly s ICAM-1] in Type 2 diabetes and controls after a glucose load [ 19 - 21 ].

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