A Kruskal–Wallis rank ordered test showed that the median GFP + cell density per ONH for each level of severity of optic nerve pathology was significantly different at 3 months (χ 2 =07.84, P= 0.0199) and 4 months of age (χ 2 =16.27, P= 0.0003), and marginally significant at 5 months of age ( Fig. 4 E).
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Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma.
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