Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.

Neuro Oncol · 2015 · PMC4416132 · PMID 25038505

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0.0600

closest p · 1.2× alpha

0.0600

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borderline significanceP = .06so close (0.05 < p ≤ 0.1)

Both MPNSTs with methylated and unmethylated RASSF1A promoter had lower expression than the benign neurofibromas ( P = .0001 and P = .05, respectively), suggesting that additional mechanisms are involved in silencing the RASSF1A gene in MPNST. For the MPNSTs, a borderline significance was seen with the second assay, between promoter hypermethylation and reduced gene expression ( P = .06; data not shown).

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