In order to ensure that the significance is not only due to two Mendelian disorders with the most pathways impacted, we also run this test when Rubinstein-Taybi syndrome and Pervasive Specified Congenital Anomalies are removed: in this case only 81 pathways are shared but the overlap is still highly significant.
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Genetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes.
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