Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression.

PLoS One · 2015 · PMC4416816 · PMID 25933092

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highly significantp value <2.2e-16actually significant

Strikingly, ten of these hypermethylated AIMS-Seq amplicons were located in the gene promoter region of the downregulated genes ( Aqp4 , Axin2 , Atad5 , Brca1 , Fads1 , Lgr5 , Phgdh , Slc1a2 , Slit2 , St3gal3 ) belonging to the expression signature of the intestinal stem cell [ 7 ], which represents a highly significant enrichment (Fisher exact test, p value <2.2e-16).

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