The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data.

PLoS One · 2015 · PMC4420286 · PMID 25942596

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an increasing trendno p-value reported

More than 50% ASC possessed either one of these two mutations and 42% ASC possessed both; 2) the frequency of four mutations (1485T, 1631T, 1762T, and 1764A) showed an increasing trend accompanied with the disease progression though the changes among groups were not significant (Jonckheere-Terpstra trend test, P > 0.05); and 3) ratios of 4 mutations (1383C, 1479C, 1479T, and 1719T) fluctuated among different disease phases.

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