Effects of cytarabine on activation of human T cells - cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid.

BMC Pharmacol Toxicol · 2015 · PMC4422044 · PMID 25934555

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The drugs showed additive enhancing effects on CD69 expression both for CD4 + and CD8 + T cells when testing double or triple combinations, and highly significant differences could then be detected (i) for CD4 + T cells when combining ATRA and valproic acid 500 μM; and (ii) especially for CD4 + cells but also CD8 + T cells when ATRA/valproic acid were combined with low cytarabine concentrations (0.01 and 0.35 μM, p <0.001).

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