STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells.

Overall, hyporesponsiveness by STAT3C + T cells was statistically highly significant compared with control-transduced T cells; however, it was not as pronounced as with FOXP3 -transduced T cells, leading to an average reduction of proliferation by 53.4 ± 23.5% ( n = 6, P < 0.001) in response to anti-CD3/anti-CD28 stimulation ( Fig. 2 B , D ) and 70.5 ± 10.4% ( n = 5, P < 0.001) in response to anti-CD3/CD58 stimulation by aAPCs, respectively ( Fig. 2 C , D ).

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