Genetic contribution to osteoarthritis development: current state of evidence.

Curr Opin Rheumatol · 2015 · PMC4423655 · PMID 25775188

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highly significantno p-value reported

Furthermore, a CpG site located 4 base pairs upstream of rs143383 shows highly significant demethylation in osteoarthritis knee cartilage compared with osteoarthritis hip cartilage, which correlates with reduced expression of the gene [ 19 ▪▪ ].

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