Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion.

Mol Cell Proteomics · 2015 · PMC4424396 · PMID 25700012

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may be significantno p-value reported

Thus, as the proteins have no sequence similarity other than in their polyQ regions, flanking domain content may be significant in determining the disease state and neuronal-specific selectivity.

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