Pan-cancer stratification of solid human epithelial tumors and cancer cell lines reveals commonalities and tissue-specific features of the CpG island methylator phenotype.

The contingency table comparing the results from the two classification algorithms yielded a highly significant level of association based on Fisher’s exact test ( P = 2.15 × 10 −67 ).

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We evaluated survival curves based on CIMP status for the 12 cancer types in our study and found significant differences in KIRC, LUSC, and UCEC (BRCA results were borderline significant at 0.06) (Figure 8 B).

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