The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output.

Mol Cell · 2015 · PMC4429956 · PMID 25866244

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In etoposide-treated cells, 236 genes were differentially expressed in PIP4K2B-depleted cells, whereas 127 genes were differentially expressed between WT-TAF3 and KK-TAF3 rescue cells, with a highly significant overlap of 30 genes ( Figure S6 D).

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