Clarithromycin vs. Gemifloxacin in Quadruple Therapy Regimens for Empiric Primary Treatment of Helicobacter pylori Infection: A Randomized Clinical Trial.

14 , 15 Several authors have reported an increasing trend in clarithromycin resistance rates in other areas of the world such as Latin America and Turkey. 16 , 17 In contrast, there was no change in the trend of H.pylori eradication rate by using PPI, clarithromycin and amoxicillin over the recent 11 years in Korea. 18 Unfortunately, inappropriate use of antibiotics, especially macrolides in Iran has led to the emergence and spread of resistant bacteria, and plans to reduce the over-prescription of antibiotics by physicians should be arranged.

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9 , 10 To tackle this problem, an alternative drug that is effective, safe, and easy to use has been searched. The eradication rate has got a decreasing trend by using clarithromycin from 2000 to 2012 in Iran.

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