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Prostate-specific antigen-based population screening for prostate cancer: current status in Japan and future perspective in Asia.

Asian J Androl · 2015 · PMC4430954 · PMID 25578935

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a decreasing trendno p-value reported
A population-based screening cohort revealed that the proportion of metastatic disease in cancer detected by screening gradually decreased according to the increased exposure rate, and a decreasing trend in the proportion of cancer with high serum PSA levels after population screening was started.

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