A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families.

As seen in the Figure, two SNPs, rs14135 and rs1475531, in the gene show highly significant marginal p-values of 9.33 × 10 − 7 and 7.08 × 10 − 7 , respectively, while other SNPs, such as rs6135305 with p-value of 3.63 × 10 − 3 , rs2423846 with p-value of 4.27 × 10 − 2 , rs1408428 with p-value of 1.77 × 10 − 2 , and rs6079611 with p-value of 3.83 × 10 − 3 , also show some marginal significance.

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