Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life.

Rapamycin-feeding resulted in a marginally significant increase in total sleep time (Treatment effect, p = 0.05) when the sexes were combined, but not when each sex was treated separately (females: Treatment effect, p = 0.10, males: Treatment effect, p = 0.26).

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Interestingly, control males showed no decline in resting metabolic rate with age, whereas it declined significantly in the rapamycin-fed group ( Fig 3F ), thus there was a highly significant Treatment X Age interaction ( p < < 0.001) in males.

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