Genetic diversity in the collaborative cross model recapitulates human West Nile virus disease outcomes.

When we assessed the relationship between these two major allele classes and the above-described symptomatic and asymptomatic disease outcomes, we found a highly significant ( P < 1e −08 ; analysis of variance [ANOVA], F 2,43 = 30.06) relationship between allele class and disease outcome such that those CC-RIX mice homozygous for the classic inbred allele showed an enhanced propensity for symptomatic disease outcomes.

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