Concordant dysregulation of miR-5p and miR-3p arms of the same precursor microRNA may be a mechanism in inducing cell proliferation and tumorigenesis: a lung cancer study.

We observed that FOXM1, CCNB1, and CCNE2 protein expressions were significantly elevated in the samples categorized as “both low” ( P = 2.52 × 10 −4 , 3.29 × 10 −4 , and 0.01 for FOXM1, CCNB1, and CCNE2, respectively), compared with the samples designated as “both high,” or “one low” ( P = 0.02, 0.02, and 0.09, respectively; the last P -value is marginally significant, but showed the same trend).

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