Overall, NK cell depletion resulted in decreased expression of NK cell cytotoxicity and inflammation ( Klrc1/Nkg2a , Klrd1/CD94 , Ncr1/Nkp46 , FasL , and Tnfa ; expression of Klrk1/Nkg2d were not affected) and fibrosis markers ( Col1a1 , Timp1 , Mmp8 , and Mmp9; Sma expression did not change) (Fig 4A and 4B ); there was a notable trend toward lower levels of IL-6, with significant decreases in the concentration of Tnfa and IL-1b at 21 days ( S4 Fig ).
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Natural killer cells promote long-term hepatobiliary inflammation in a low-dose rotavirus model of experimental biliary atresia.
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