Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer.

BMC Cancer · 2015 · PMC4440599 · PMID 25998617

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highly significantno p-value reported

More recently, we have reported that native bLf downregulates survivin gene expression in SW480 colon cancer cells [ 7 ], and Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells [ 41 ] Here however it was found that MDA-MB-231 cells showed highly significant decreases in survivin protein expression levels, as well as strong increases in IAP inhibitors SMAC/DIABLO and HTRA2.

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