The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin.

Elife · 2015 · PMC4442312 · PMID 25922909

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Around 18% of the detected peaks showed highly significant (more than fivefold decrease) changes in H3K9 tri-methylation in cells lacking ORCA ( Figure 5B , Supplementary file 1 and total H3K9 in Figure 5—figure supplement 1Aa ).

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