Inhibition of T-Type Voltage Sensitive Calcium Channel Reduces Load-Induced OA in Mice and Suppresses the Catabolic Effect of Bone Mechanical Stress on Chondrocytes.

Although there were no significant differences in the levels of aggrecan and collagen II across the various conditions, we found a decreasing trend in the expression level of Mmp13 mRNA in chondrocytes treated with CM from FSS NNC and static NNC vs . chondrocytes treated with CM from FSS UT ( Fig 4 ).

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