These expanded CSF T cells were enriched for cryptococcal-antigen specific CD4+ and CD8+ T cells that are critical in protection from the fungus [ 39 ], secreting the protective cytokine, IFN-γ [ 40 ] as well as a lack of highly elevated CSF levels of typical T-cell specific Th2 cytokines IL-4 and IL-13 (IL13 was barely significant)[ 41 ], or typical Th17 cytokines IL-17 or GM-CSF (also not shown).
1
—
—