It may be significant that Asp-387 (or glutamate) is almost invariant in the ETS recognition helix, with only class III proteins displaying a substitution to glutamine ( 32 ).
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Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.
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