Reminder systems to improve patient adherence to tuberculosis clinic appointments for diagnosis and treatment.

In Spain, where children were given 12 months of isoniazid treatment to be supervised at home by their parents, attendance at the final clinic appointment was increased by a policy of routine phone calls every three months (RR 1.44, 95% CI 1.21 to 1.72), routine home visits every three months by a specialist nurse (RR 1.46, 95% CI 1.23 to 1.74), and by routine doctor clinic appointments every three months (RR 1.20, 95% CI 0.98 to 1.47), although this third policy did not quite reach statistical significance (one trial, 318 participants, Analysis 3.2 ).

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