The clustering of functionally related genes contributes to CNV-mediated disease.

Genome Res · 2015 · PMC4448677 · PMID 25887030

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highly significantno p-value reported

In particular, the single largest cluster of functionally related genes of approximately five genes was highly significant in both DECIPHER and NIJMEGEN de novo CNVs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.