Across the different types of QTLs/GWAS that we compared to our mQTLs, we noticed an interesting trend: QTLs associated with the earliest steps of transcription (dsQTLs associated with chromatin accessibility) had the strongest overlap with mQTLs, while moving progressively towards phenotype, the enrichment decreased at each stage ( Fig. 4 ).
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A pooling-based approach to mapping genetic variants associated with DNA methylation.
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